Ethics

 

J. Anomaly. What is Informed Choice? Polygenic Risk and Reproductive Autonomy. Fertility & Sterility Dialog (2023).

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M. de Souza. Testing Embryos for IQ. Law, Technology and Humans (2022).

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G. Lázaro-Muñoz, S. Pereira, S. Carmi, and T. Lencz. Screening embryos for polygenic conditions and traits: ethical considerations for an emerging technology. Genetics in Medicine (2021).

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J. Anomaly. Creating Future People: The Ethics of Genetic Enhancement. London, UK: Routledge Publishing (2020).

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Policy

A. Abu-El-Haija, …, and Michael F. Murray, on behalf of the ACMG Professional Practice and Guidelines Committee. The clinical application of polygenic risk scores: A points to consider statement of the American College of Medical Genetics and Genomics (ACMG). Genetics in Medicine (2023).

D. K. Griffin and A. T. Gordon. Preimplantation Testing for Polygenic Disease (PGT-P): Brave New World or Mad Pursuit? DNA (2023).

T. Lencz, M. Sabatello, A. Docherty, R. E. Peterson, T. Soda, …, C. Walss-Bass, and L. K. Davis. Concerns about the use of polygenic embryo screening for psychiatric and cognitive traits. The Lancet Psychiatry (2022).

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A. Polyakov, D. J. Amor, …, Y. Mizrachi, and G. Rozen. Polygenic risk score for embryo selection—not ready for prime time. Human Reproduction (2022).

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N. R. Treff, J. Savulescu, I. de Melo-Martin, L. P. Shulman, and E. C. Feinberg. Should preimplantation genetic testing for polygenic disease be offered to all – or none? Fertility and Sterility (2022).

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ISPG Ethics Committee. Advisory on the Use of Polygenic Risk Scores to Screen Embryos for Adult Mental Conditions. (2021).

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Munday S, Savulescu J. Three models for the regulation of polygenic scores in reproduction. J Med Ethics. (2021)

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F. Forzano, O. Antonova, …, C. van El, and M. Genuardi (on behalf of the Executive Committee of the European Society of Human Genetics and the Public and Professional Policy Committee of the European Society of Human Genetics). The use of polygenic risk scores in pre-implantation genetic testing: an unproven, unethical practice. European Journal of Human Genetics (2021).

Related: ESHRE supports the position of ESHG on embryo selection based on polygenic risk scores (ESHRE)

Related: L. C. A. M. Tellier, N. R. Treff, S. Hsu, L. Lello, and E. Widen  Scientific refutation of ESHG statement on embryo selection. European Journal of Human Genetics (2022).

Related: F. Forzano, O. Antonova, …, C. van El, and M. Genuardi. Reply to Letter by Tellier et al., ‘Scientific refutation of ESHG statement on embryo selection’. European Journal of Human Genetics (2022).

 

Resources of the National Society of Genetic Counselors:

J. Flanagan. Polygenic Risk Scores and In-Vitro Fertilization: What to Consider When Using Genetic Testing.

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J. Austin. Using genetic testing to select embryos with lower risk for schizophrenia: What should I know?